Ayesha Sitlani,Carl P. Sparrow,Shilpa Pandit,Jon H. Condra,Dana D. Wood,Timothy S. Fisher
申请号：
US13242831
公开号：
US20120082680A1
申请日:
2011.09.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
