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PROCESSES TO PRODUCE CERTAIN 2 (PYRIDINE 3 YL)THIAZOLES
专利权人:
发明人:
ROSS RONALD,DEAMICIS CARL,ZHU YUANMING
申请号:
IN9845/DELNP/2014
公开号:
IN2014DN09845A
申请日:
2014.11.20
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The invention disclosed in this document is related to the field of processes to produce certain 2- (pyridine- 3 -yl)thiazoles as intermediates for the synthesis of pesticidal thiazole amides. Compounds (I) and (II) are cyclized to produce compound (III). This step is conducted in the presence of a base when compound (II) is in the form of a salt. Suitable bases include but are not limited to sodium bicarbonate , potassium bicarbonate, sodium carbonate , cesium carbonate , potassium carbonate, sodium hydroxide , potassium hydroxide , sodium bisulfate , sodium acetate , potassium acetate , ammonium hydroxide, sodium methoxide, potassium methoxide , sodium ethoxide, potassium ethoxide, triethylamine and pyridine. The reaction can be conducted at ambient temperature and pressure , but higher or lower temperatures and pressures can be used if desired. The reaction is conducted in a polar protic solvent. Examples of such solvents include, but are not limited to, n -butanol , isopropanol , n -propanol , ethandl, methanol , and water.
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