PROBLEM TO BE SOLVED: To provide a compound that have P2Xreceptor antagonism and is effective for preventing or treating nociceptive pain, inflammatory pain, or neuropathic pain.SOLUTION: Provided is a compound containing N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]-3-(pyridin-2-yl)propionic acid amide, 2-ethyl-3-hydroxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide, 2-ethyl-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]nicotinamide or the like.SELECTED DRAWING: Figure 1【課題】P2X4受容体拮抗作用を有し、侵害受容性疼痛、炎症性疼痛、又は神経因性疼痛の予防又は治療に有効な化合物の提供。【解決手段】N-[4-(2-オキソ-2,3-ジヒドロ-1H-ナフト[1,2-e][1,4]-ジアゼピン-5-イル)フェニル]-3-(ピリジン-2-イル)プロピオン酸アミド、2-エチル-3-ヒドロキシ-N-[4-(2-オキソ-2,3-ジヒドロ-1H-ナフト[1,2-e][1,4]-ジアゼピン-5-イル)フェニル]ベンズアミド、2-エチル-N-[4-(2-オキソ-2,3-ジヒドロ-1H-ナフト[1,2-e][1,4]-ジアゼピン-5-イル)フェニル]ニコチンアミド等を含む化合物。【選択図】図1