PROBLEM TO BE SOLVED: To provide a compound that have P2Xreceptor antagonism and is effective for preventing or treating nociceptive pain, inflammatory pain, or neuropathic pain.SOLUTION: Provided is a compound containing N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]-3-(pyridin-2-yl)propionic acid amide, 2-ethyl-3-hydroxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide, 2-ethyl-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]nicotinamide or the like.SELECTED DRAWING: Figure 1【課題】Ｐ２Ｘ４受容体拮抗作用を有し、侵害受容性疼痛、炎症性疼痛、又は神経因性疼痛の予防又は治療に有効な化合物の提供。【解決手段】Ｎ－［４－（２－オキソ－２，３－ジヒドロ－１Ｈ－ナフト［１，２－ｅ］［１，４］－ジアゼピン－５－イル）フェニル］－３－（ピリジン－２－イル）プロピオン酸アミド、２－エチル－３－ヒドロキシ－Ｎ－［４－（２－オキソ－２，３－ジヒドロ－１Ｈ－ナフト［１，２－ｅ］［１，４］－ジアゼピン－５－イル）フェニル］ベンズアミド、２－エチル－Ｎ－［４－（２－オキソ－２，３－ジヒドロ－１Ｈ－ナフト［１，２－ｅ］［１，４］－ジアゼピン－５－イル）フェニル］ニコチンアミド等を含む化合物。【選択図】図１
