According to the present invention, a porous membrane containing a polymer is included, and the porous membrane has a layered dense portion having a minimum pore diameter in the membrane, and extends from the dense portion toward at least one surface of the porous membrane. An immunoisolation membrane whose pore diameter continuously increases in the thickness direction, and a transplantation chamber for enclosing a biological component, wherein the above-mentioned immunoisolation is provided on at least a part of the surface forming the inside and the outside There is provided a transplant chamber having a membrane, and a transplant device in which the biological composition is encapsulated in the transplant chamber. The immunoisolation membrane of the present invention is less likely to cause a decrease in substance permeability and can be manufactured at low cost.本発明により、ポリマーを含む多孔質膜を含み、上記多孔質膜は、孔径が最小となる層状の緻密部位を膜内に有し、上記緻密部位から上記多孔質膜の少なくとも一方の表面に向かって厚み方向で孔径が連続的に増加している免疫隔離膜、生物学的構成物を内包するための移植用チャンバーであって、内部と外部とを形成する面の少なくとも一部に上記免疫隔離膜を有する移植用チャンバー、ならびに上記移植用チャンバーに上記生物学的構成物が内包されている移植用デバイスが提供される。本発明の免疫隔離膜は、物質透過性の低下が生じにくく、安価に製造が可能である。
