Морозов Дмитрий Валентинович (RU),Ломкова Екатерина Александровна (RU),Яковлев Александр Олегович (RU),Шитикова Виктория Олеговна (RU),Ряховская Анастасия Михайловна (RU),Иванов Роман Алексеевич (RU)
申请号：
RU2016152691
公开号：
RU2016152691A
申请日:
2016.12.30
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: pharmaceuticals.SUBSTANCE: invention relates to the medical pharmacology, in particular to the recombinant monoclonal antibody to TNFα (adalimumab) improved aqueous pharmaceutical compositions and to their preparation method. Invention also relates to the use recombinant monoclonal antibody to TNFα (adalimumab) improved aqueous pharmaceutical compositions for the TNFα mediated diseases treatment.EFFECT: proposed invention allows to prevent the physic-chemical instability, expressed in the aggregates and protein fragments formation or proteins modification in the solution, and also prevents instability during the freezing and thawing, stirring and shaking.22 cl, 9 dwg, 10 tbl, 5 ex
