Nucleic acid that suppresses MEX3B gene expression, MEX3B gene expression inhibitor, method for suppressing MEX3B gene expression, and preventive or therapeutic agent for diseases caused by MEX3B gene expression
Nucleic acid that has low cytotoxicity as a side effect and can suppress MEX3B gene expression, MEX3B gene expression inhibitor containing the nucleic acid, method for suppressing MEX3B gene expression, and preventive or therapeutic agent for diseases caused by MEX3B gene expression To provide. An antisense oligonucleotide having a sequence complementary to an oligonucleotide comprising at least 10 consecutive nucleotides in an untranslated region in an exon of the MEX3B gene, or a double-stranded RNA comprising at least 20 consecutive nucleotides in the untranslated region Alternatively, a nucleic acid that suppresses the expression of the MEX3B gene, which is a DNA encoding the double-stranded RNA.副作用としての細胞毒性が少なく、ＭＥＸ３Ｂ遺伝子の発現を抑制することができる核酸、上記核酸を含むＭＥＸ３Ｂ遺伝子発現抑制剤、ＭＥＸ３Ｂ遺伝子発現を抑制する方法及びＭＥＸ３Ｂ遺伝子発現に起因する疾病の予防又は治療剤を提供すること。 ＭＥＸ３Ｂ遺伝子のエクソン中の非翻訳領域中の連続する少なくとも１０ヌクレオチドを含むオリゴヌクレオチドに相補的な配列を有するアンチセンスオリゴヌクレオチド、又は 前記非翻訳領域中の連続する少なくとも２０ヌクレオチドを含む二本鎖ＲＮＡ若しくは前記二本鎖ＲＮＡをコードするＤＮＡである、ＭＥＸ３Ｂ遺伝子の発現を抑制する核酸。
