Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound methods and systems using intersecting ultrasound beams non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier non-invasive neuromodulation of the spinal cord by ultrasound energy methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions.
