Koninklijke Nederlandse Akademie van Wetenschappen
发明人:
CLEVERS, Johannes Carolus,BARKER, Nicholas,HAEGEBARTH, Andrea,VAN DE WETERING, Marcus Lambertus
申请号：
HUE08793835
公开号：
HUE032118T2
申请日:
2008.08.08
申请国别(地区):
HU
年份:
2017
代理人:
摘要：
The invention relates to the field of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue. In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising - optionally preparing a cell suspension from a tissue or organ sample - contacting said cell suspension with an Lgr4, 5 or 6 binding compound - identify the cells bound to said binding compound - optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.
