Jasbir Seehra,John Knopf,Robert S. Pearsall,Asya Grinberg,Ravindra Kumar
申请号：
US14142094
公开号：
US09452197B2
申请日:
2013.12.27
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.
