PROBLEM TO BE SOLVED: To provide means that can conserve a biological dose (RBE) under a uniform physical dose in a proton beam therapy.SOLUTION: In a malignant tumor therapy by irradiation of a uniform physical dose of proton beam within the superposition of plural Bragg peaks (SOBP) of irradiated proton beam, a sensitizer for proton beam therapy containing an RNA synthesis inhibitor as an active ingredient used for adjusting a biological dose (RBE) within SOBP is provided. The invention also provides a method of proton beam therapy comprising radiating a uniform physical dose of proton beam within SOBP to the affected area to which a sensitizer containing an RNA synthesis inhibitor as an active ingredient is administered.SELECTED DRAWING: Figure 7COPYRIGHT: (C)2017,JPO&INPIT【課題】陽子線治療において、均一の物理線量下において生物線量(RBE)も一定にできる手段を提供すること。【解決手段】照射陽子線の複数のブラッグピークの重ね合わせ(SOBP)内で均一物理線量の陽子線を照射して行われる悪性腫瘍の治療において、SOBP内での生物線量(RBE)を調整するために用いられる、RNA合成阻害剤を有効成分とする陽子線治療用増感剤。RNA合成阻害剤を有効成分とする増感剤を投与した患部に、SOBP内で均一物理線量の陽子線を照射することを含む、陽子線治療方法。【選択図】図7
