Hsieng Sen Lu;Ji Li;William Gleason Richards;Wenyan Shen
发明人:
Ji Li,Wenyan Shen,Hsieng Sen Lu,William Gleason Richards
申请号：
US12603303
公开号：
US08101184B2
申请日:
2009.10.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
