WON, CHEOL HEEKR,원철희,MIN, DAL HEEKR,민달희,KIM, SEONG CHANKR,김성찬
申请号：
KR1020150034187
公开号：
KR1020160110762A
申请日:
2015.03.12
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention provides a method for quickly synthesizing a product at a high yield as compared to a conventional method with respect to a high-temperature synthesis reaction using hydrothermal reaction and/or microwave based on carbon nanoparticles which are surface-coated with PEG or PEI. In the case of a synthesis method through a microwave, according to a change in a molecular weight of PEI used in reaction, the gene delivery finality to synthesized particles is differently determined. In the case of carbon nanoparticles coated with PEI, various types of fluorescent dyes can be bonded through surface modification and thus can be applied to a multiple imaging system. In the case of carbon nanoparticles coated with PEG, as different types of pharmaceutical active ingredients and genes or the like can be stacked by using an aromatic structure inside a particle, it is suitable for a chemotherapy formulation with respect to a tumor and/or a disease cell. In addition, the heating ability by light-sensitivity when a near-infrared laser is radiated has an apoptosis ability specific to a tumor and/or a disease cell near a particle. Therefore, according to the present invention, the complex therapy (the chemotherapy and/or light-sensitive heat generating therapy) based on carbon nanoparticles which are surface-coated with PEG or PEI is excellent, a surface of the particle is modified according to a purpose to be bonded with a target ligand, and it can be used as target therapeutics for selectively targeting a target cell or a target tissue. In addition, the gene delivery efficiency for a cell and/or a tissue based on high biocompatibility of the particle is excellent to be used in basic research fields, cosmetic fields, medicine and medicine and pharmacy fields, and the like.COPYRIGHT KIPO 2016본 발명은 PEG 또는 PEI로 표면 코팅되어있는 탄소나노입자를 기반으로 수열반응 및/또는 마이크로웨이브를 이용한 고온 합성반응에 대하여, 종래의 방법에 비해 빠르고 높은 수율의 생성물을 합성하는 방법을 제공함에 있다. 마이크로웨이브를 통한 합성방법의 경우, 반응에 사용한 PEI의 분자량의 변화에 따라 합성된
