THÉRAPIE COMBINÉE PAR UN INTERFÉRON ET DES ANDROGRAPHOLIDES DESTINÉS À LA SCLÉROSE EN PLAQUES

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专利权人:

LLC;INNOBIOSCIENCE

发明人:

HANCKE OROZCO, JUAN, L.,BURGOS, RAFAEL

申请号：

EP12859754

公开号：

EP2670406A4

申请日:

2012.12.19

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The effectiveness of interferon for treating multiple sclerosis and other demyelinating diseases is synergistically potentiated by concomitant administration of a compound of Formula (I): wherein R1 is H, alkyl or OH, R2 is hydroxyalkyl or alkyl-O-L1, R3 is H or OH, X is C(&boxH；CH2), CH(OH), or spirooxirane-2, Z is CH2CH(OH) or C(=0), and R4 is an optionally substituted L2-alkyl or L2-alkenyl, wherein L2 is an optionally substituted 3-furanyl or 3-fur-3-enyl moiety.

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