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COMBINAISON D'ANTICORPS ANTI-PD-1 ET DE RAYONNEMENT POUR TRAITER LE CANCER
专利权人:
INC.;REGENERON PHARMACEUTICALS
发明人:
SKOKOS, DIMITRIS,LOWY, ISRAEL
申请号:
CA3023984
公开号:
CA3023984A1
申请日:
2017.05.12
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present disclosure provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., solid tumors). The methods of the present disclosure comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody), optionally, in combination with radiation therapy. In certain embodiments, the methods comprise administering hypo-fractionated radiation in combination with an anti-PD-1 antibody or a fragment thereof to achieve a prolonged abscopal effect in tumor inhibition.
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