The present disclosure relates to a medical diagnosis apparatus and a method of operating the same. The medical diagnosis apparatus performs measurement based on a preset diagnosis system environment in response to a measurement start instruction input from a user, and only if the apparatus receives an instruction for changing the diagnosis system environment, the apparatus performs measurement based on a changed diagnosis system environment in response to the instruction. In the apparatus and method, a workflow is arranged to perform measurement effectively which is a main purpose of the medical diagnosis apparatus, thereby reducing time for measurement or diagnosis and users operation failure and providing convenience in operation.