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Benzothiazepin�] and benzothiadiazepine derivatives with ileal bile acid transport�] (IBAT) inhibitory activity for the treatment of hyperlipidemia
专利权人:
Albireo AB
发明人:
STARKE, Ingemar,DAHLSTROM, Mikael, Ulf, Johan,BLOMBERG, David,ALENFALK, Suzanne,SKJARET, Tore,LEMURELL, Malin
申请号:
DK02765013
公开号:
DK1427423T5
申请日:
2002.09.05
申请国别(地区):
DK
年份:
2018
代理人:
摘要:
The present invention relates to compounds of formula (I) wherein R<;SUP>;v<;/SUP>;, R<;SUP>;1<;/SUP>;, R<;SUP>;2<;/SUP>;, R<;SUP>;x<;/SUP>;, R<;SUP>;y<;/SUP>;, M, R<;SUP>;z<;/SUP>;, v, R<;SUP>;3<;/SUP>;, R<;SUP>;4<;/SUP>;, R<;SUP>;5 <;/SUP>;and R<;SUP>;6 <;/SUP>;are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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