THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;VA BOSTON HEALTHCARE SYSTEM;Childrens Medical Center Corporation;Children's Medical Center Corporation
发明人:
DENNIS P. ORGILL,GEORGE F. MURPHY,MARKUS H. FRANK,NATASHA Y. FRANK
申请号：
BR112015028193
公开号：
BR112015028193A2
申请日:
2014.05.09
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
A wound healing support comprising a grafted collagen glycosaminoglycan support with a stem cell population, wherein at least 80% of the stem cell population is abcb5 + stem cells. 2. wound healing support, characterized in that it comprises a grafted collagen glycosaminoglycan support with a stem cell population, less than 50% of the cells of the composition are abcb5 (-) cells. 3. wound healing support comprising a grafted collagen glycosaminoglycan support with an abcb5 + stem cell population, wherein the cell population includes less than 5% keratinocytes and / or epidermal cells. 4. A wound healing support comprising a grafted collagen glycosaminoglycan support with an abcb5 + ocular stem cell population, wherein the cell population is free of non-ocular cells. 5. wound healing support comprising a collagen glycosaminoglycan support grafted to a population of abcb5 + stem cells isolated from a tissue of an individual, wherein abcb5 + stem cells were separated from other cells in the individual. using an abcb5 specific antibody. Support according to any one of claims 1 to 5, characterized in that the abcb5 + stem cells are dermal mesenchymal abcb5 + stem cells. A carrier according to any one of claims 1 to 6, characterized in that at least 85% of the stem cell population is abcb5 + stem cells. Support according to any one of claims 1 to 6, characterized in that at least 90% of the stem cell population is abcb5 + stem cells. Support according to any one of claims 1 to 8, characterized in that the support is a porous matrix of cross-linked collagen and glycosaminoglycan. Support according to claim 9, characterized in that the collagen is bovine tendon collagen. Support according to any one of claims 1 to 10, characterized in that the support includes a semipermeable layer. Support according to Claim 11, characterized in that the semipermeable layer is polysiloxane (silicone). Carrier according to any one of claims 1 to 12, characterized in that the carrier is a ne
