FRIZZLED-BINDING AGENTS AND USES THEREOF农业专利-农业专业知识服务系统

发明人:: GURNEY, AUSTIN L.,葛尼奥斯汀,葛尼奧斯汀,SATO, AARON KEN,沙图亚伦,沙圖亞倫,AXELROD, FUMIKO TAKADA,艾斯洛得富米可,艾斯洛得富米可,HOEY, TIMOTHY CHARLES,荷伊提摩太,荷伊提摩太,SATYAL, SANJEEV H.,沙陀沙尼芙,沙陀沙尼芙,MITRA, SATYAJIT SUJIT KUMAR,米特

摘要：: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.本發明提供新穎之抗癌劑類,其包括但不限於與人捲曲受體結合之抗體。在人捲曲受體內適合作為抗癌劑之標靶的新穎表位亦被識別。本發明另提供使用該等劑類或抗體之方法,諸如使用該等劑類或抗體以抑制Wnt傳訊及/或抑制腫瘤生長之方法。