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PHARMACEUTICAL COMPOSITION FOR TREATING DERMATITIS COMPRISING FRACTION OF FOENICULUM VULGARE EXTRACT
专利权人:
DONGGUK UNIVERSITY GYEONGJU CAMPUS INDUSTRY-ACADEMY COOPERATION FOUNDATION;동국대학교 경주캠퍼스 산학협력단
发明人:
SHIN, HEUNG MOOK,신흥묵,LEE, DONG UNG,이동웅,YANG, IN JUN,양인준,SHIN, HEUNG MOOKKR,LEE, DONG UNGKR,YANG, IN JUNKR
申请号:
KR1020140121793
公开号:
KR1020160032310A
申请日:
2014.09.15
申请国别(地区):
KR
年份:
2016
代理人:
摘要:
The present invention relates to a methylene chloride fraction of a Foeniculum vulgare Gaertner fruit extract, which exhibits effects of ameliorating or treating dermatitis. More specifically, the present invention relates to a pharmaceutical composition containing a methylene chloride fraction of a Foeniculum vulgare Gaertner fruit extract which has excellent effects of treating inflammation in an animal model with dermatitis. In addition, the composition of the present invention is also outstanding in inhibition of the expression of proinflammatory mediators and proinflammatory cytokines and also inhibition of nuclear translocation of NF-κB p65. The present invention further relates to an external skin application composition therefor. According to the present invention, used in the composition is Foeniculum vulgare Gaertner which is an edible plant. Thus, the composition can be safely used since the composition does not cause cytotoxicity.본 발명은 피부염 개선 또는 치료 효과를 나타내는 회향(Foeniculum vulgare) 열매 추출물의 메틸렌클로라이드(Methylene Chloride) 분획물에 관한 것으로서, 보다 구체적으로 본 발명은 전-염증성 사이토카인과 전-염증 매개인자의 발현을 저해하는 효과 및 NF-κB p65의 핵 전위를 억제하는 효과가 우수하며, 피부염 동물 모델의 염증 치료 효과가 탁월한 회향 열매 추출물의 메틸렌클로라이드 분획물을 포함하는 약학적 조성물 및 피부 외용제 조성물에 관한 것이다. 본 발명에 따른 조성물은 식용 식물인 회향을 이용함으로써 세포에 독성을 나타내지 않아 안전하게 사용가능한 장점이 있다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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