David T. Curiel,Osvaldo Podhajcer,Maria Veronica Lopez
申请号：
US16797291
公开号：
US20200270639A1
申请日:
2020.02.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein is a conditionally-replicating serotype 5 adenovirus or adenoviral vector expressing a mutant E1A protein under control of a promoter that is responsive to hypoxia and inflammation and one or more immune modulators under control of a tumor-specific promoter. The adenovirus or adenoviral vector also comprises serotype 3 fiber and hexon proteins. Also provided is a method of inducing cytotoxicity in tumor cells using a composition containing the adenovirus or adenoviral vector.
