DEVELOPMENT CENTER FOR BIOTECHNOLOGY;CHANG GUNG MEMORIAL HOSPITAL;ACADEMIA SINICA
发明人:
Alice L. Yu,John Yu,Ya-Hui Wang,Chuan-Lung Hsu,Yi-Chang Chen,Ying-Yung Lok
申请号：
US14223800
公开号：
US20140363372A1
申请日:
2014.03.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. The antibody binds to an epitope in an intercoil domain of TMCC3. A method of diagnosing or assessing a cancer condition includes assessing a level of expression or activity of a transmembrane and coiled-coil domains protein 3 (TMCC3) in a sample, wherein an increase in the level of expression of activity of TMCC3 as compared to a standard indicates the presence of cancer stem cells in the sample.
