CDRD VENTURES INC.;ZYMEWORKS INC.;THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT
发明人:
申请号：
IL24152415
公开号：
IL241524A
申请日:
2015.09.10
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having structure (I).
