The Trustees Of The University Of Pennsylvania;Wyeth LLC
发明人:
WALSH, FRANK S.,ZALESKA, MARGARET M.,HOWLAND, DAVID S.,HOLZBAUR-HOWLAND, ERIKA L.F.,TCHISTIAKOVA, LIOUDMILA,KARIM, RIYEZ,KELLEY, PAMELA,TAN, XIANG-YANG,KWAK, SEUNG POON,WALLACE, KAREN,WEBER, NICHOLAS
申请号：
PL11161564
公开号：
PL2407486T3
申请日:
2006.08.14
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
