Provided is a dispensing box for a drug-containing ampoule. The dispensing box for the drug-containing ampoule includes a partition member including a partition wall for partitioning a plurality of unit cells in which ampoules are stored, a shutter opening or closing a lower portion of each of the unit cells partitioned by the partition member, a driving unit operating the shutter, a conveyer on which a dropping ampoule is seated when the lower end of each of the unit cells is opened, and a discharge hole defined in an end of the conveyer to dispense the ampoule seated on the conveyer when the conveyer is operated. A drug storage matrix in which the drug-containing ampoule is stored may be provided, and a shutter device for dispensing the drug-containing ampoule may be provided to easily dispense the drug-containing ampoule.