Bharat S. Savaliya;Sigrid De Keersmaecker;Dirk De Vos;Denis Ermolatev;Hans Steenackers;Jozef Vanderleyden;Erik Van Der Eycken
发明人:
Sigrid De Keersmaecker,Dirk De Vos,Denis Ermolatev,Hans Steenackers,Erik Van Der Eycken,Jozef Vanderleyden,Bharat S. Savaliya
申请号：
US13526235
公开号：
US08906915B2
申请日:
2012.06.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.
