BYUN, YOUNG RO,AHMED, AL-HILAL TASLIM,JEON, OK CHEOL,MOON, HYUN TAE,YUN, YISUK,KIM, KYUNGJIN
申请号：
EP12889309
公开号：
EP2925786A4
申请日:
2012.11.29
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention relates to a method for preparing an end site-specific macromolecule-bile acid oligomer conjugate, comprising conjugating a bile acid oligomer which is prepared by oligomerization of two or more bile acid monomers to the terminal site of a macromolecule； a method for body absorption of an end site-specific macromolecule-bile acid oligomer conjugate, comprising administering the macromolecule-bile acid oligomer conjugate prepared by the above method to a subject orally； an end site-specific macromolecule-bile acid oligomer conjugate wherein the bile acid oligomer is conjugated to the terminal site of macromolecule； a composition comprising the conjugate； an oral formulation for macromolecule comprising the conjugate, a solubilizer, an excipient, a disintegrant, a binder, and a lubricant； a pharmaceutical composition comprising a heparin-bile acid oligomer conjugate wherein the bile acid oligomer is conjugated to the terminal site of heparin； and a method for treating thrombosis using said composition.
