A hand cover includes a protective housing secured to an adjustment mechanism. The protective housing inhibits contact between the hand and the external environment. The adjustment mechanism secures the hand cover to the user. An optional upper access aperture provides air circulation and access to the hand. An optional lateral access aperture also provides access to the hand. An optional positioning mechanism helps maintain the hand cover in place. Attachment anchors for restraints or exercise bands may be provided and devices for orienting and securing IV lines may be provided.