Salt type camsilate (1R, 1 R, 4R) - 4 '- methoxy - 5 - methyl - [5 - (6' - prop - 1 - in - 1 - il) pyridin-3-yl] - 3 '- diespiro H inden cyclohexane - [1,2' - 1 '2' -] - 4 '- imidazole Amine； Pharmaceutical composition, Pharmaceutical combination, use in the Treatment or prevention of diseases such as Down Syndrome, disease d And Alzheimer's disease, Memory loss, dementia, among others.
A process for the preparation of a camsylate salt ((1S)-(+)-10 camphorsulfonic acid) of (1r,1'R,4R)- 4-methoxy-5"-methyl-6'-[5-(prop-1-yn-1-yl)pyridin- 3-yl]-3'H-dispiro[cyclohexane-1,2'-inden-1'2'-imidazole]-4"-amine is disclosed as well as pharmaceutical compositions containing the salt and therapeutic uses of the salt for treating A²-related pathologies such as Alzheimer's Disease, Down's Syndrome, ²-amyloid angiopathy and conditions such as dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's Disease, progressive supranuclear palsy or cortical basal degeneration.<；p>；SE DESCRIBE UNA SAL DE TIPO CAMSILATO DE (1R, 1&rsquo；R,4R)-4-METOXI-5&rsquo；&rsquo；-METIL-6&rsquo；-[5-(PROP-1-IN-1-IL)PIRIDIN-3-IL]-3&rsquo；H-DIESPIRO[CICLOHEXANO-1,2&rsquo；-INDEN-1&rsquo；2&rsquo；&rsquo；-IMIDAZOL]-4&rsquo；&rsquo；-AMINA, COMPOSICIÓ；N FARMACÉ；UTICA QUE CONTIENE LA SAL Y SU USO PARA TRATAR PATOLOGÍ；AS RELACIONADAS CON AB, TAL COMO LA ENFERMEDAD DE ALZHEIMER, SÍ；NDROME DE DOWN, ANGIOPATÍ；A B-AMILOIDE Y AFECCIONES TALES COMO LA DEMENCIA, INCLUÍ；DA LA DEMENCIA DE ORIGEN MIXTO VASCULAR Y DEGENERATIVO, DEMENCIA PRESENIL, DEMENCIA SENIL Y DEMENCIA ASOCIADA CON LA ENFERMEDAD DE PARKINSON, PARÁ；LISIS SUPRANUCLEAR PROGRESIVA O DEGENERACIÓ；N CORTICOBASAL. ADEMÁ；S SE DESCRIBE UN PROCESO DE PREPARACIÓ；N DE LA SAL.<；/p>；
