ARIMURA, HIDETOSHI,TAKAHASHI, YOSHITAKE,YAMAUCHI, KOJI
申请号：
HK09106595.7
公开号：
HK1129123B
申请日:
2009.07.20
申请国别(地区):
HK
年份:
2012
代理人:
摘要：
Disclosed are: a safe bio-degradable/absorbable polymer having an extremely low metal catalyst content while retaining properties desired for a medical implant a process for the production of the polymer and a method for reducing the content of a metal catalyst in a bio-degradable/absorbable polymer, which can be applied on an industrial scale. Specifically, disclosed is a process for the production of a bio-degradable/absorbable polymer having a content of a metal catalyst of less than 1 ppm in terms of a metal, comprising the following steps (1) and (2): (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 40/60 to 60/40 in the presence of a metal catalyst to produce a copolymer and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a ratio ranging from 25/75 to 45/55 by volume at a temperature lower than 40˚C, and then drying the copolymer. Also specifically disclosed is a process for the production of a bio-degradable/absorbable polymer having a content of a metal catalyst of less than 1 ppm in terms of a metal, comprising the following steps (1) and (2): (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 65/35 to 85/15 in the presence of a metal catalyst to produce a copolymer and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a ratio ranging from 45/55 to 55/45 by volume at a temperature lower than 40˚C, and then drying the copolymer.polymère biodégradable/absorbable fiable à teneur en catalyseur métallique très faible, conservant néanmoins des propriétés souhaitées pour un implant médical, et procédé de production ainsi que procédé de réduction de la teneur susmentionnée dans un tel polymère, applicable à léchelle industrielle. On décrit spécifiquement un procédé de production de ce polymère à teneur en catalyseur métallique inférieure à 1 ppm pour le métal, qui comprend les étapes suivantes (1,2): (1) copolymérisation de lactide et
