MUDDE, Geert,BROOME, Paul Christopher,JACOBS, Frederick William,LANGER, Christof
申请号：
HUE14724102
公开号：
HUE037252T2
申请日:
2014.05.16
申请国别(地区):
HU
年份:
2018
代理人:
摘要：
The invention provides for an immunogenic composition comprising a. a directed adjuvant comprising at least an anti-CD32 moiety linked to a TLR9 ligand and a first peptidic alpha-helix； and b. a gastrin-17 peptide immunogen linked to a second peptidic alpha-helix coiled to the first alpha-helix, which peptide immunogen is any of (i) human gastrin-17 comprising the amino acid sequence of SEQ ID 1, or a fragment thereof comprising the amino acid sequence of SEQ ID 2, or at least the 4 N-terminal amino acids of SEQ ID 2； (ii) an analog of (i), preferably of rhesus monkey or murine origin； and/or (iii) a functionally active variant of any of (i) or (ii), with one, two, three or four point mutations in the amino acid sequence of SEQ ID 2. The invention further provides a kit for producing such immunogenic composition, a vaccine comprising such immunogenic composition and its medical use, such as for treating gastrin dependent diseases.
