Disclosed herein is a method of fractional treatment of tissue, the method comprising: creating at least one micro hole in a target tissue and either a) applying pressure on said target tissue to decrease the patency of said at least one micro hole administering material and/or fluid and/or drug onto said target tissue releasing said applied pressure on said target tissue to increase the patency of said at least one micro hole and propelling said material and/or fluid and/or drug into said at least one micro hole or b) administering material and/or fluid and/or drug onto said target tissue under sub- atmospheric pressure conditions, the patency of said at least one micro hole being decreased increasing the atmospheric pressure to atmospheric or above atmospheric conditions to thereby increase the patency of said at least one micro hole and propelling said material and/or fluid/ and/or drug into said at least one micro hole.
