Provided are a cyclic peptide compound or a pharmacologically acceptable salt thereof capable of inhibiting parakeratosis of skin, and a method for producing the same. This method comprises subjecting a cyclic peptide compound of Formula (I):or a pharmacologically acceptable salt thereof, wherein Xaa1 and Xaa5 are each optionally substituted Ser, optionally substituted Thr, or optionally substituted Tyr； Xaa2 is optionally substituted Ile, optionally substituted Val, or optionally substituted Leu； Xaa3 and Xaa4 are each optionally substituted Asn, optionally substituted Gln, optionally substituted Asp, or optionally substituted Glu； and R1 is a group of Formula (II):—CO—(CH2)n—NH— (II),or Formula (III):—NH—(CH2)n—CO— (III),wherein n is the same as defined above, and in Formula (I), the linkage between Cys and Cys is a peptide bond or a disulfide bond, and the other linkages are peptide bonds,to cyclization with a compound of Formula (IV):Cys-R1-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Cys (IV),wherein, Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, and R1 are the same as defined above.
