DR VACHASPATI DUBEY,DR RUCHI TIWARI,DR PRANAYWAL,MS ANKITA WAL,DR GAURAV TIWARI
申请号：
IN201711038841
公开号：
IN201711038841A
申请日:
2017.11.01
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The objective of the research work was to design novel niosome containing both hydrophilic and hydrophobic drug by using modified ethanol ejection method was used to formulate niosome. The niosome formulation showed higher drug entrapment and controlled drug™s release. Small multilamellar vesicles, with sizes ranging from about 0.05 μm, were successfully obtained. Results indicated a significant influence of phospholipid amounts on niosome size and encapsulation efficiency. Due to their composition variability and structural properties, niosome are extremely versatile leading to a large number of applications including pharmaceutical, cosmetics and food industrial fields. Niosome morphology was studied by SEM, niosome ranged in size from 0.05 μm. No drug crystals were visible in SEM-images, regardless of the preparation technique or the loaded drug. FT-IR graphs of the pure drug, soya lecithin, cholesterol and their physical mixtures was performed and the FT-IR graphs are shown in from the figures it is noted that there is no possible interactions between drugs and the other. The average percent drug entrapment efficiency of optimized formulation showed a maximum drug entrapment for both the drug™s. The drug™s release profile of optimized formulation showed a best fit to the desired control drug release profile among all the formulations. Phospholipid concentration showed a positive effect and it was found that when phospholipid concentration was increased the encapsulation efficiencies of formulation increased. A study showed that niosome were not stable at high temperature but formulations are most stable when stored at lower temperature i.e. 4oC. So, in the niosome we were successfully incorporated both hydrophilic and hydrophobic drugs and it can be further used for formulation development.
