SIVAKUMAR, PALLAVUR V.,GILBERTSON, DEBRA G.,SNAVELY, MARSHALL D.,MABRY, GEORGE R.,YI, EUGENE C.,YAO, YUE,PRESNELL, SCOTT R.
申请号：
HRP20140244
公开号：
HRP20140244T1
申请日:
2014.03.17
申请国别(地区):
HR
年份:
2014
代理人:
摘要：
There is provided an isolated antibody that binds to the extracellular domain of PDGFR² and neutralizes PDGFR² activity, said antibody comprising a V L domain comprising CDRs LCDR1, LCDR2, and LCDR3 and a V H domain comprising CDRs HCDR1, HCDR2, and HCDR3, wherein: LCDR1 has the amino acid sequence shown in SEQ ID NO: 433, optionally the amino acid sequence shown in SEQ ID NO: 443； LCDR2 has the amino acid sequence shown in SEQ ID NO: 434； LCDR3 has the amino acid sequence shown in SEQ ID NO: 435, optionally the amino acid sequence shown in SEQ ID NO: 444； HCDR1 has the amino acid sequence shown in SEQ ID NO: 436, optionally the amino acid sequence shown in SEQ ID NO: 445； HCDR2 has the amino acid sequence shown in SEQ ID NO: 437； HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 438-442
