КАБРАЛ-ЛИЛЛИ Донна (US),МАЙЕР Лоренс (CA),ТАРДИ Пол (CA),УОТКИНС Дэвид (US),ЦЗЭН И (US)
申请号：
RU2014120475/15
公开号：
RU2014120475A
申请日:
2012.10.15
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Lyophilized liposome composition in the gel phase, wherein said liposomes are in the gel phase phase exhibit a melting temperature (T) of at least 25 ° C and stably associated with at least two therapeutic and / or diagnostic agents, and substantially no It contains an internal cryoprotectant, wherein the cryoprotectant and presented outwardly from said liposomes and wherein when said liposomal composition is reproduced in the gel phase, the average diameter of liposomes is saved compared to said composition prior to lyophilization, and such agents are retained in liposomah.2. Composition according to claim. 1, wherein said liposomes have a phase transition temperature (T), which is at least 37 ° C.3. Composition according to Claim. 1, wherein said agents are encapsulated fixed ratio and wherein when said composition is reproduced, the ratio of the agents is changed to not more than 25% compared to said composition before liofilizatsiey.4. Composition according to Claim. 1, wherein the average diameter of the liposomes is increased by not more than 25% after lyophilization and during playback of said liposomes in comparison to said value measured prior liofilizatsiey.5. A composition according to claim. 4, wherein the average diameter of the liposomes is increased by not more than 15% after lyophilization and during playback of said liposomes in comparison to said value measured prior liofilizatsiey.6. A composition according to claim. 5, where the average diameter of the liposomes is increased by not more than 10% after lyophilization and during playback of said liposomes in comparison to said value measured prior liofilizatsiey.7. Composition according to claim1. Лиофилизированная липосомальная композиция в гелевой фазе, в которой указанные липосомы в гелевой фазе проявляют фазовую температуру плавления (Tc) по меньшей мере 25°C и стабильно ассоциированы с по меньшей мере двумя терапевтическими и/или диагностическими агентами, и, по существу, не содержат внутре
