A catheter for optical biopsy comprises a forceps (2) for tissue sampling on its distal end and a forceps control device (1), a light source and a device for imaging and analysis of a scanned tissue on its proximal end, with the distal and the proximal ends interconnected with an elongated sheath (4) containing a Bowden (3) with a control cable or wire and at least one optical fibre (5). The sheath (4), made of flexible plastic, provides a lengthwise channel (6) for the Bowden (3) placement, whereas the channel (6) is open with a fissure (7) along the full length of the sheath (4).