Rita M. O'Neil;Wellstat Therapeutics Corporation;Rita M. ONeil
发明人:
James Dennen O'Neil,Shalini Sharma,Ramachandran Arudchandran,James Dennen ONeil
申请号：
US13783680
公开号：
US20130336949A1
申请日:
2013.03.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I. The uric acid-lowering effects of the compounds of this invention are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, cognitive impairment, early-onset essential hypertension, and Plasmodium falciparum-induced inflammation.
