A method of treating a subject having a deficient immune response is described. The method includes administering a therapeutically effective amount of non-immune drug, or an analog or metabolite thereof, known to induce one or more autoimmune syndromes to the subject. Drugs known to induce one or more autoimmune syndromes, such as lupus-like syndromes, include immune checkpoint inhibitor blockers. Methods of identifying drugs capable of enhancing immunity are also described.
