The method of the periplast for generating crosslinking is disclosed, by the periplast for the crosslinking that this class method generates, and the tissue products comprising such periplast. This method comprises: (1) is dehydrated the periplast comprising collagen, to form the periplast comprising collagen of dehydration And (2) periplast comprising collagen of irradiation dehydration, so that at least part crosslinking of the periplast comprising collagen of dehydration.