Philip Tan;John W. Blankenship;Peter Armstrong Thompson;Peter Robert Baum;Sateesh Kumar Natarajan
发明人:
Peter Armstrong Thompson,Peter Robert Baum,Philip Tan,John W. Blankenship,Sateesh Kumar Natarajan
申请号：
US13122383
公开号：
US09493564B2
申请日:
2009.10.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an HLA-G agonist, an HGF agonist, an IL-35 agonist, a PD-1 agonist, a BTLA agonist, a LIGHT antagonist, a GITRL antagonist or a CD40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.
