BILLEN DENIS,CHUBB NATHAN ANTHONY LOGAN,CURTIS MICHAEL,GREENWOOD SEAN DW,MENON SANJAY,STUK TIMOTHY,VAILLANCOURT VALERIE A.
申请号：
NZ61454712
公开号：
NZ614547A
申请日:
2012.02.23
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
The disclosure relates to spirocyclic isoxazoline derivatives of formula (V.1) or formula (V.2), stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables within the formula are described within the specification. Example compounds include: 1-(5&rsquo-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3&rsquoH-spiro[azetidine-3,1&rsquo-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone (R)-1-(5&rsquo-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3&rsquoH-spiro[azetidine-3,1&rsquo-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone (S)-1-(5&rsquo-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3&rsquoH-spiro[azetidine-3,1&rsquo-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone 1-(5&rsquo-(5-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3&rsquol-lspiro[azetidine-3,1&rsquo-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone (R)-1-(5&rsquo-(5-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3&rsquoH-spiro[azetidine-3,1&rsquo-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone.
