BRIAN COCHRAN,BRIAN M. FOX,BRIAN S. LUCAS,FILISATY VOUNATSOS,LAWRENCE R. MCGEE,MATTHEW BIO,SARAH WORTMAN,SEAN WIEDEMANN,SEBASTIEN CAILLE,YUANQING FANG
申请号：
BR112015031004
公开号：
BR112015031004A2
申请日:
2014.06.09
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
abstract "manufacturing processes and crystalline forms of an mdm2 inhibitor" the present invention provides processes for making acetic acid 2 - ((3r, 5r, 6s) -5- (3-chlorophenyl) -6- (4-chlorophenyl) - 1 - ((s) -1- (isopropylsulfonyl) -3-methylbutan-2-yl) -3-methyl-2-oxopiperidin-3-yl), as well as intermediates and processes for making the intermediates. Crystalline forms are also provided. of the compound and the intermediates.resumo “processos para fabricação e formas cristalinas de um inibidor de mdm2" a presente invenção provê processos para fazer ácido acético 2-((3r,5r,6s)-5-(3-clorofenil)-6-(4-clorofenil)-1-((s)-1-(isopropilsulfonil)-3-metilbutan-2-il)-3-metil-2-oxopiperidin-3-il), bem como intermediários e processos para fazer os intermediários. também são providas formas cristalinas do composto e os intermediários.
