A method of forming a tablet includes the steps of pre-blending an active pharmaceuticalingredient susceptible to tackiness and a blending additive with a first mixingeffort to form a pre-blend mixture, wherein the first mixing effort and a secondmixing effort, resulting from mixing at least one excipient with the pre-blendmixture, form a blend suitable for direct compression and compressing the blendto form the tablet. One way of achieving the first mixing effort is to pre-blendfor an extended period of time. The method allows for directly compressing theblend without the need for a granulation step or roller compression. One suchactive pharmaceutical ingredient susceptible to tackiness is ibuprofen.
