Refers to a composition comprising Chondroitin sulfate of 0.1% to 2% by weight, glucosamine hydrochloride from 1% to 25% by weight, connective tissue growth factor of 50 ng \/ mg to 500 ng \/ mg.Transforming Growth Factor Beta 1 10 ng \/ mg to 100ng \/ mg and an aqueous solution comprising Water, buffer solution and \/ or Dimethyl sulfoxide.Said composition is useful in the Treatment or prevention of degenerative Disc disease, disc Injury, Pain, among otherSe refiere a una composicion que comprende sulfato de condroitina de 0.1% a 2 % en peso, clorhidrato de glucosamina de 1% a 25% en peso, factor de crecimiento de tejido conjuntivo de 50 ng/mg a 500 ng/mg, factor de crecimiento transformante beta 1 de 10 ng/mg a 100ng/mg y una solucion acuosa que comprende agua, solucion amortiguadora y/o sulfoxido de dimetilo. Dicha composicion es util en el tratamiento o prevencion de una enfermedad discal degenerativa, lesion de disco, dolor, entre otras