您的位置: 首页 > 农业专利 > 详情页

plasmalogen compounds, pharmaceutical compositions containing them and methods for treating aging diseases
专利权人:
PHENOMENOME DISCOVERIES INC.
发明人:
DAYAN GOODENOWE,M. AMIN KHAN,PAUL L. WOOD,PEARSON AHIAHONU,RISHIKESH MANKIDY
申请号:
BRPI0922619
公开号:
BRPI0922619A2
申请日:
2009.12.18
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
Described herein are routes of synthesis and therapeutic uses of 1-alkyl, 2-acyl glycerol derivatives of formula I: which when administered to mammalian biological systems result in increased cellular concentrations of specific sn-2 substituted ethanolamine plasmalogens independent of the ether lipid synthesis capacity of the system. Elevating levels of the specific sn-2 substituted species in this way can cause lowering of membrane cholesterol levels and the lowering of amyloid secretion. These compounds can be used for the treatment or prevention of diseases of aging associated with increased membrane cholesterol, increased amyloid, and decreased plasmalogen levels, such as neurodegeneration (including Alzheimer's disease, Parkinson's disease and age-related macular degeneration), cognitive impairment, dementia, cancer (e.g. prostate, lung, breast, ovarian, and kidney cancers), osteoporosis, bipolar disorder and vascular diseases (such as atherosclerosis, hypercholesterolemia).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充