DÉRIVÉS DE LA PYRAZINE ET LEUR UTILISATION COMME INHIBITEURS DES PROTÉINES KINASE

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专利权人:

AKINION PHARMACEUTICALS AB

发明人:

申请号：

EP09706385.3

公开号：

EP2252597B1

申请日:

2009.01.28

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present invention relates to compounds of the general formula (I) wherein R 1 , R 2 and R 3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.

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