GROUP B STREPTOCOCCUS POLYSACCHARIDE PROTEIN CONJUGATES METHODS FOR PRODUCING CONJUGATES IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATES AND USES THEREOF
ANDERSON ANNALIESA SYBIL,BHUPENDER BHALLA AMARDEEP SINGH,DONALD ROBERT G K,GU JIANXIN,JANSEN KATHRIN UTE,KAINTHAN RAJESH KUMAR,KHANDKE LAKSHMI,KIM JIN HWAN,LIBERATOR PAUL,PRASAD AVVARI KRISHNA,RUPPEN
申请号：
IN201717038004
公开号：
IN201717038004A
申请日:
2017.10.26
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The invention relates to immunogenic polysaccharide protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae commonly referred to as group B streptococcus (GBS) and a carrier protein wherein the CP is selected from the group consisting of serotypes Ia Ib II III IV V VI VII VIII and IX and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide protein conjugates wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
