PROBLEM TO BE SOLVED: To provide chemoembolization treatment compositions for delivery of anti-angiogenic agents, and production methods thereof.SOLUTION: The invention provides a chemoembolization treatment composition for delivery of an anti-angiogenic agent useful for treating solid tumor cancers, where the anti-angiogenic agent, e.g., sunitinib and imatinib, is loaded in an anionic drug eluting bead such as a sulphonate-modified polyvinyl alcohol hydrogel bead and a carboxyl-modified polyvinyl alcohol-co-sodium acrylate bead. Also provided is a method for preparing a chemoembolization treatment composition for delivery of an anti-angiogenic agent comprising a step of contacting the bead suspended and swollen in a continuous liquid vehicle, such as water, with an aqueous solution of sugar of the anti-angiogenic agent.SELECTED DRAWING: None【課題】抗血管新生薬デリバリー用化学塞栓療法組成物、及びその製造法の提供。【解決手段】スルホン酸修飾ポリビニルアルコールヒドロゲルビーズ及びカルボキシル修飾ポリビニルアルコール－ｃｏ－アクリル酸ナトリウムビーズ等のアニオン性薬剤溶出性ビーズに充填された、スニチニブ及びイマチニブ等の抗血管新生薬を含む、固形腫瘍癌の処置に有効な、抗血管新生薬デリバリー用化学塞栓療法組成物。水等の連続液体のビヒクル中に懸濁され、膨張した該ビーズと該抗血管新生薬の糖等の水溶液と接触させる工程を含む、抗血管新生薬デリバリー用化学塞栓療法組成物の調製方法。【選択図】なし
