MILBURN, PETER J,BANDIN, DAVID LINARES,SILVA, DIEGO
申请号：
NZ58342908
公开号：
NZ583429A
申请日:
2008.08.25
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is polypeptide for modulating mast cell activation, said polypeptide comprising a NEDD 9 Src homology 3 (SH3) domain sequence that consists of a sequence as set forth in SEQ ID NO: 8 or a variant or fragment thereof wherein: (i) the variant consists of a sequence as set forth in anyone of SEQ ID NOs: 16, 33-49,145-148, 156-159, 165-168, or 176-179 and (ii) the fragment consists of a sequence as set forth in anyone of SEQ ID NOs: 122-125, or 134-137. Also disclosed is the use of a polypeptide comprising a NEDD9 Src homology 3 (SH3) domain ammo acid sequence for the manufacture of a medicament for the treatment of a hypersensitivity disease or disorder arising from mast cell activation
