Igor BENDIK,Bettina BOEHLENDORF,Hubert Paul HUG,Bernd MUSSLER,Nathalie RICHARD
申请号：
US16605627
公开号：
US20200129531A1
申请日:
2018.04.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to systemic detoxification by using extracts of Withania somnifera (ashwagandha) and its Nrf2-activating components withaferin-A, 12-deoxywithastramonolide, and Quresimine A. When ingested, the transcription factor Nrf2, which is a crucial element in intracellular detoxification pathways, leads to elimination of potentially toxic compounds. In parallel, the expression of inflammatory cytokines is decreased. Therefore, the extract can be used to reduce the adverse effects of air pollution generally (and especially of particulate air pollution), which includes: cardiovascular problems, respiratory diseases, and chronic inflammation of tissues that come into contact with air borne particles.
